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Lady Mastermind is a fictional supervillain in the Marvel Comics Universe. Regan Wyngarde is the daughter of Jason Wyngarde, the original Mastermind. Her half-sisters are Martinique Wyngarde, the second Mastermind, who now shares her codename, and the X-Men's Pixie. Like her sister and father, Regan possesses the ability to cast telepathic illusions. Although the character originally appeared as a villain, she would later have a brief stint as an X-Man. A short time after joining, she betrayed the X-Men.

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